DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

绝对不稳定性理论在尾流稳定性分析方面的研究

介绍了绝对／对流不稳定性的理论框架，并应用于钝体尾流剪切层的稳定性分析研究中。钝体尾流可以认为是局部平行流，而局部平行流的稳定性分析可以归结为Ｏｒｒ－Ｓｏｍｍｅｒｆｅｌｄ方程的求解。Ｏ－Ｓ方程求解化为一个复广义矩阵问题ＡＸ＝ωＢＸ，并分别约化Ａ，Ｂ为上Ｈｅｓｓｅｎｂｅｒｇ阵和上三角阵，通过Ｃｈｅｂｙｓｈｅｖ配置法可以求出特征值。最后对于Ｇａｕｓｓ尾流计算模型，给出了其在不同Ｒｅｙｎｏｌｄｓ下，流动     

企业标准体系的建立与完善及对策

介绍企业标准体系的基本构成、特征和建立的原则,就建立完善的企业技术标准体系、制定企业管理标准体系和工作标准等阐述体系建立的途径,并对企业标准体系的管理、完善和改进等有关的几个问题进行探讨。     

减压活门性能试验台系统方案设计

主要介绍了减压活门性能试验台的实现机理、采用的方案。     

rom 15 sel

with primary goat embryonic fibroblast showed no difference from traditional feederlayer-based culture method used in mouse and human. The putative primary EG colonies were multilayer clumps ofcompact cel     

数控车削加工仿真系统结构研究

根据实际加工情况提出了一种虚拟NC车削加工的仿真系统的设计及实现原理。在Visual C++平台上利用OpenGL技术建立虚拟加工机床数字化模型,用C++语言实现物理仿真相关的各个数学模型的建立,进行虚拟环境下数控车削加工的几何仿真及物理仿真,实现产品的虚拟车削制造。     

INITIALIZATION METHODS FOR GROUP TRACKING

ＩＮＩＴＩＡＬＩＺＡＴＩＯＮＭＥＴＨＯＤＳＦＯＲＧＲＯＵＰＴＲＡＣＫＩＮＧＹａｎｇＣｈｅｕｇｙａｎｇ；ＱｕＪｉａｎｍｉｎｇ；ＭａｏＳｈｉｙｉ（ＢｅｉｊｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＡｅｒｏｎａｕｔｉｃｓａｎｄＡｓｔｒｏｎａｕｔｉｃｓ，Ｂｅｉｊｎｇ，Ｃ...     

航天产品工艺定型阶段工艺文件的编制与审查

从编制《工艺定型标准化要求》、审定有关工艺定型文件和编写《工艺定型标准化审查报告》等方面浅述航天产品工艺定型阶段应做好的标准化文件的编制与审查,并对其工作内容作了介绍。     

用于卫星推力室的新型催化剂

卫星上安装有用于轨道和姿态控制的小推力推力室。推力由三氧化二铝基的铱催化剂分解无水肼而产生。铱催化剂的主要缺点是成本高和生产技术复杂。目前的工作是把钼(M)、钨(W)的碳化物与氮化物的合成过程与成型联系起来,形成有大、中孔隙的新型催化剂,来代替昂贵的传统催化剂30%铱——三氧化二铝(即shell-405_(TM))。在这种新的工艺中,首先是制备胶状的钨酸和钼酸;然后把这些材料与有机聚合物混合,使之生成胶体溶液;再挤压成型。其次把生成的这些中间过渡产品送去加热处理,焚烧掉有机聚合物得到所期望的有大、中孔隙的氧化物。最后一步是按照Boudart和Volpi方法利用挤出物制备氮化物和碳化物。本文给出了用2N推力室试验新催化剂的主要试验结果,同时与Shell 405~(TM)的试验结果进行了比较。试验表明新催化剂有如下特点:比表面积大;能承受高达1100K的烧结温度;热试时室压和推力高度稳定,催化剂机械强度高。新催化剂的主要优点是生产工艺更简单而且成本更低。     

计算机帧时间对半实物仿真的影响

半实物仿真试验中,要求计算机帧时间与计算积分步长相一致,但在实际试验中不容易精确地做到。本文分析了这种不一致给半实物仿真试验带来的影响,给出了解决的办法,文章中还给出了一实例来说明。